Haemoglobin variant and falsely high haemoglobin A1c value on ion-exchange chromatography
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چکیده
منابع مشابه
Persistent fetal haemoglobin and falsely high glycosylated haemoglobin levels.
Some of the routine methods of measuring glycosylated haemoglobin depend on its difference in charge from haemoglobin A and do not distinguish between glycosylated haemoglobin and fetal haemoglobin. Two insulin dependent diabetics showed persistent discrepancies between their capillary blood glucose values and their glycosylated haemoglobin values measured by agar gel electrophoresis: the blood...
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Glycated haemoglobin (HbA1c) measured by high performance liquid chromatography (HPLC) in a 20 year old female with insulin dependent diabetes mellitus was consistently within the normal range although her daily blood glucose values were > 11.1 mmol/l. HbA1c measured by immunoagglutination and fructosamine was elevated and correlated with the patient's blood glucose values. The HPLC chromatogra...
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Various laboratory and patient-related factors can result in falsely high or low glycated haemoglobin (HbA1c) measurements, and haemoglobin (Hb) variants that interfere with laboratory readings is an important cause of this. We report a case of a rare Hb variant, Hb Santa Juana, manifesting as a falsely high HbA1c in a 62-year-old patient with type 2 diabetes mellitus. The patient presented wit...
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Haemoglobin A(1c) (HbA(1c)) is due to celebrate its 40th birthday. Many people would argue that the clinical studies relating the test to diabetes complications while in its late 20s are likely to be its finest ever achievement. However, this article looks at how HbA(1c) has matured since then and discusses in detail how its many strengths and idiosyncrasies as a marker of glycaemic risk have, ...
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BACKGROUND Epidemiological and experimental evidence suggests that inadequate sleep can cause both obesity and impaired glucose tolerance. Short sleep duration in childhood appears to have a greater impact on the risk for adult obesity than adult sleep duration. The long-term effects of childhood sleep on glucose metabolism have not been investigated. The authors assessed the associations betwe...
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ژورنال
عنوان ژورنال: Singapore Medical Journal
سال: 2014
ISSN: 0037-5675
DOI: 10.11622/smedj.2014159